Transcription repression via CpG DNA hyper-methylation of p16INK4a (CDKN2A) (Platt et al., 2002), the TGF-beta type II receptor (TbetaRII, TGFBR2) (Di Bartolo et al., 2008), and PDZ-LIM domain-containing protein 2 (PDLIM2) (Sun et al., 2015) promoters have been detected in KSHV-infected primary effusion lymphoma (PEL) lines. Here, PDLIM2 is linked to primary effusion lymphoma.