CDH13 and Kaposi's sarcoma: Several of the hyper-methylated promoters we identified in KS are among the few promoters that were previously reported and confirmed as hyper-methylated in KSHV-infected cells, such as the transforming growth factor–β type II receptor (TGFBR2/TβRII) (Di Bartolo et al., 2008), and EH Domain Containing 3 (EHD3) (Journo et al., 2018) in PEL, and Cadherin 13 (CDH13) (Shamay et al., 2006) in LANA expressing endothelial TIME cells.