Fusobacterium nucleatum promoted CRC through the interactions between fusobacterial lectin Fap2 and host polysaccharide and NK cells receptor TIGHT or adhesion between FadA and E-cadherin, as well as modulations of the tumor-associated immune cell and pro-inflammatory microenvironment (Kostic et al., 2013; Rubinstein et al., 2013; Gur et al., 2015; Abed et al., 2016; Ye et al., 2017). Here, CDH1 is linked to neoplasm.