TNF and colorectal cancer: NF-κB activation is also found in colorectal cancer and colitis-related tumors, which is responsible for the production of a variety of proinflammatory mediators and cytokines, such as the prostaglandin gene E2 (PGE2), inducible nitric oxide synthase (iNOS), COX-2, TNF-α, IL-6 and IL-1β,which in turn play a key role in the development of colorectal cancer (Karki et al., 2017; Ferrer-Mayorga et al., 2019).