The neuroepithelial stem cell protein commonly known as nestin, first described as an antigen of rat-401 against embryonic spinal cord and later identified as a class VI intermediate filament protein (80), has been shown to be expressed in neuroepithelial stem cells, and is highly expressed in several types of human malignancies, including higher grade GBM. This evidence concerns the gene GFAP and glioblastoma.