GBM is one of various tumors which highly expresses VEGF and its receptors, resulting in highly vascularized tumors and increased microvasculature compared to other normal tissues (162), and is an important target in glioblastoma aberrant VEGFR2 signaling, which is an important pathway affecting survival, proliferation, migration, and vessel permeability in tumor cells (163). The gene discussed is VEGFA; the disease is glioblastoma.