On the one hand, for TAMs, GSCs could facilitate chemo-attraction and recruit TAMs to the tumor site upon the hypoxic conditions, prompt the growth of macrophages, and induce the polarization of TAMs into the immunosuppressive M2 phenotype by secreting chemokines and growth factors such as VEGF, TGF-β1, neurotensin, SDF1, and sCSF-1 (202–206). The gene discussed is CXCL12; the disease is neoplasm.