The bone morphogenic proteins (BMPs) involved in promoting normal neural precursor differentiation into astrocytes and post-transcriptional modification using miRNA, have been demonstrated to play a positive role in the stem cell niche of the adult brain, increase in GSC differentiation, and suppression of glioblastoma tumorigenicity in vivo, leading to the elimination of GSCs and sensitization of GBM to chemotherapeutics (2, 171). Here, CLN5 is linked to glioblastoma.