In 2018, Zhang et al.demonstrated that LGR5 has a variety of roles, including promoting GSC epithelial-mesenchymal transition (EMT) by activating the Wnt/β-catenin pathway in vitro and in vivo, and should be an effective indicator of prognosis in GBM, along with predicting glioma recurrence (95). This evidence concerns the gene LGR5 and glioblastoma.