Because of the loss of mismatch repair protein gene (17), tumor cells showed relative poor differentiation and relatively more mucinous tissue and necrotic components exist (18), more CD3+, CD4+, CD8+, CD20+, and CD68+ cell infiltration and showed higher microvessel density (MVD) (19), resulting in different image grayscale distribution, which caused differences in image histogram features and texture features. This evidence concerns the gene CD8A and neoplasm.