TNF and liver cancer: HSP70 can enhance the immunosuppressant function of T regulatory cells (Tregs) and downregulate the secretion of cytokines IFN-γ and TNF-α (28, 29) Data obtained from nude mice bearing HepG2- and SMMC-7721-xenografted tumors confirmed that WNQP showed pro-apoptotic effects on liver cancers while inhibiting tumor growth.