By comparing the two sets of data, we found that our conclusion is similar to them, but our patients have a younger onset age than them, this may be because our patients are all IDH-wt glioma patients, and these characteristics of molecular (IDH-wt) might lead to a tendency toward a younger age of onset in GBM, and the primary LGG patients was much more younger than the primary GBM patients. Here, IDH1 is linked to central nervous system cancer.