Pilskog et al, for example, have shown the predictive value of basal IL-6 in response to sunitinib, while sIL-6 receptor, the receptor of IL-6 that mediate the trans-signaling of IL6, added the prediction of the length of progression-free survival for people with clear cell renal cell carcinoma (104). The gene discussed is IL6; the disease is clear cell renal carcinoma.