Especially, miR-99a had been confirmed to be significantly down-regulated in HCC and be appraised as an independent prognostic factor for inhibiting the growth of HCC by inducing cell cycle arrest (64), as well as miR-139-5p as a tumor suppressor gene could target ETS1, VEGFR and SPOCK1 to inhibit cell proliferation and invasion in HCC (19, 65, 66). This evidence concerns the gene KDR and hepatocellular carcinoma.