FOXO1 and hepatocellular carcinoma: Our results indicated that HCC patients in the highly expressed FOXO1 group exhibited a better survival rate than the lowly expressed FOXO1 group (p = 0.0089) (Figure 5D), revealing that FOXO1 could be served as a tumor suppressor gene to improve the good prognosis of HCC patients, which is agree with these previous studies (41).