CYP3A4 and hepatocellular carcinoma: For example, the up-regulated expressions of miR-452-5p, miR-1180-3p and miR-4746-5p could significantly inhibit the expression of the tumor suppressor gene CYP3A4 to cause a remarkably poor prognosis of HCC patients (p = 0.0032) (Figures 5A, B and Tables S3, S5).