FOXO1 and glioblastoma: Interestingly, previous studies had reported that E2F1 can activate the expression of mir-224 and mir-452 to inhibit the tumor suppressor gene TXNIP to promote glioblastoma metastasis (53), and that E2F1 and FOXM1 can activate the miR-21-5p and miR-96-5p to inhibit FOXO1 (54–56), which further supports our conclusions.