Similarly, down-regulated miR-5589-5p, miR-139-3p, miR-139-5p and miR-125b -5p can synergistically promote the up-regulated expression of oncogenic genes CDK1 and CCNA2 to result in the significantly poor prognosis for HCC patients (p <0.01) (Figures 4A, C, D and Tables S3, S4). This evidence concerns the gene CCNA2 and hepatocellular carcinoma.