EGFR and hepatocellular carcinoma: Previous studies have revealed that the up-regulated miR-452-3p can promote the proliferation and migration of hepatocellular carcinoma cells via targeting CPEB3/EGFR axis in HCC (57), which is agreement with our target prediction results (Table S3), and this up-regulated miR-1180-3p can involve in the regulation of apoptosis via targeting NF-KB in HCC (58), as well as miR-3677-3p was significantly up-regulated in cirrhotic patients with antral vasodilation (59).