Moreover, the down-regulated miR-125b-5p could induce the up-regulation of its target CD16 to promote tumor progression and lead to a poorly clinical prognosis for HCC patients (67), as well as miR-101-3p had been proved to be down-regulated and could target SOX9 to inhibit cell proliferation and metastasis in HCC (68, 69). This evidence concerns the gene SOX9 and hepatocellular carcinoma.