(49) have quantified intratumoral heterogeneity on breast DCE-MRI by using a subregion-based feature extraction method for predicting ER status, human epidermal growth factor receptor 2 (HER2) status, and triple-negative breast cancer, achieving accuracy of 73.53, 82.35, and 77.45%, respectively. Here, ESR1 is linked to triple-negative breast carcinoma.