DICER1 and osteosarcoma: Next, we examined the expression of DICER1-AS1 in osteosarcoma cancer sample, in TCGA and target database, osteosarcoma samples have neither with differentiation of drug resistance with drug sensitivity, nor normal control data, so we choose the surrounding normal tissues as the control, we extract their FPKM data and make comparison, the results revealed that it was significantly downregulated in osteosarcoma cancer samples and then surrounding normal tissues (Figure 1B, Supplementary Figure 3).