On the contrary, when we upregulated the DICER1-AS1 level by lentivirus-infection of DICER1-AS1 in SJSA-1 or MNNG/HOS cells, the multi-drugresistant OS cells, as revealed by real-time PCR (Figures 1H, J), the drug-resistance capability against Carb and Dox was reduced in SJSA-1 cell (Figure 1I) and this is also the case in MNNG/HOS cell except for Dox (Figure 1K). Here, DICER1 is linked to infection.