CD38 and Miyoshi myopathy: Anti-CD38 antibodies exert their anti-MM activity by different mechanisms of action including classical FC-dependent immune effector mechanisms, namely the antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) and the complement-dependent cytotoxicity (CDC), and direct and immunomodulatory effects (43) (Figure 1).