SLAMF7 and Miyoshi myopathy: A virus-free CAR gene transfer using advanced Sleeping Beauty (SB) transposon technology. SB transposition in CAR-T engineering is attractive due to the high rate of stable CAR gene transfer enabled by optimized hyperactive SB100X transposase and transposon combinations, encoded by mRNA and minicircle DNA, respectively, as preferred vector embodiments (CARAMBA PROJECT).The allogenic anti-SLAMF7-CAR T cell (UCARTCS1) is the first ‘off-the-shelf’ CAR T-cell product in MM