In vivo, BCMA-overexpressing tumors increased neo-angiogenesis and transcription of genes crucial for osteoclast activation, adhesion, and angiogenesis/metastasis, as well as genes mediating immune inhibition including programmed death ligand 1 (PDL1), transforming growth factor β (TGF- β), and interleukin 10 (IL-10) to orchestrate the complex interplay between myeloma and microenvironment cells (120). This evidence concerns the gene CD274 and plasma cell myeloma.