TNF and Miyoshi myopathy: In vitro experiments have documented that both T lymphocyte subpopulations (CD4+ and CD8+) contribute to the antibody-induced lysis of MM cells, associated to autologous T-cell activation, documented by increased secretion of IFNγ, IL-2, IL-6, IL-10, and TNFα in a dose dependent manner, in T-cells obtained from both newly diagnosed and RRMM patients (Figure 3).