Also, AOM/DSS treatment significantly increased the frequency of PD-L1-positive cells both in tumor (P = 0.034 for WT and P = 0.020 for Nrf2 KO; Figures 5B, F) and non-tumor areas (P = 0.034 for WT and P = 0.020 for Nrf2 KO; Figures 5B, D) in WT and Nrf2 KO female mice, but to a lesser extent in Nrf2 KO female mice, when compared with WT mice; the difference was not statistically significant. Here, NFE2L2 is linked to neoplasm.