Similar to PD-L1 expression, iNOS and COX-2 protein levels were strongly elevated by AOM/DSS treatment only in WT females (P = 0.002 for iNOS and P = 0.018 for COX-2), not in Nrf2 KO females (Figures 2B, F, H). The gene discussed is PTGS2; the disease is infectious otitis media.