76% was the percentage of BRAF executed in our sample and the incidence of BRAF mutations was slightly greater than 50% and 65% reported a BRAF V600E mutation most cases were analyzed after the year 2013 when target therapies were diffusely employed in clinical practice; in addition, more cases among those analyzed harbored stage IV tumors rather than stage IIIB-IIIC melanomas. This evidence concerns the gene BRAF and melanoma.