After prognostic analysis with PD-L1/B7-H4 combined with FOXP3/CD163, it was found that the double high group (high PD-L1 high CD163, high PD-L1 high FOXP3 and high B7-H4 high FOXP3) shortened overall survival time, confirming that the inhibitory tumor microenvironment led to poor prognosis. The gene discussed is VTCN1; the disease is neoplasm.