Genetic variants in the BMP/Smad4/Hamp hepcidin-regulating pathway, such as Hamp rs1882694, BMP2 rs1979855, rs3178250, and rs1980499, were associated with OS, local-regional progression-free survival, progression-free survival, and distant metastasis-free survival in patients receiving definitive RT for NSCLC but not rs12456284 (55). This evidence concerns the gene HAMP and non-small cell lung carcinoma.