DKK3 and pancreas disorder: A comprehensive set of murine injury models focusing on liver and pancreas allows us to unravel i) regulatory patterns of DKK3 upon injury, ii) DKK3 as limiting factor of pancreas and liver regeneration, iii) compartment specific effects of DKK3 loss in, for example, hepatocytes versus stem cells and acinar versus ductal cells,[21, 32, 33] and iv) finally translate these data to human cohorts of acute and chronic liver/pancreatic disease models.