DKK3 and alkaline phosphatase measurement: AP is characterized by acinar cell death, de‐differentiation of acinar cells (ADM), inflammation, and fibrosis.[21] After caerulein‐induced AP, Dkk3−/−, and Dkk3+/+ mice displayed similar levels of necrosis, ADM lesions, edema, and inflammatory infiltration scores (Figure 5B,C) at 12, 24, and 48 h post‐injury, suggesting that DKK3 expression does not influence the initial tissue damage.