In contrast to other DKK proteins, DKK3 is not only a classical Wnt modulator, but also limits TGF‐β‐signaling during prostate morphogenesis, and maintains pancreatic cancer cells in a de‐differentiated state.[38, 39, 40] However, the effect of DKK3 on iPSC formation is unclear. This evidence concerns the gene DKK3 and pancreatic neoplasm.