Chronic DDC feeding resembles human cholestatic liver disease involving 1) biliary remodeling, which gives rise to progenitor, marks positive ductular reactions, 2) periductular fibrosis, and 3) chronic inflammation.[61] This predominantly biliary damage results in the expansion of ductular reactions resembling induced LPC closely to the portal mesenchyme after three weeks and at later stages of fibrosis induction.[35, 62] Accordingly, we induced cholestasis in wildtype and Dkk3‐knockout animals and quantified fibrosis and serological parameters (Figure 4G). Here, DKK3 is linked to Cholestatic liver disease.