Validation via RT‐PCR and/or western blotting confirmed strong upregulation of the Hh‐ligands Indian hedgehog (Ihh) and Sonic hedgehog (SHH) as well as the Hh‐receptor Smoothened (Smo) in Dkk3−/− animals already 24 h after pancreatitis induction, followed by a significant increase of the target gene glioma‐associated oncogene 1 (Gli1) 96 h post‐injury (Figure 6L,M and Figure S5F, Supporting Information). Here, DKK3 is linked to pancreatitis.