Notably, in most human populations, there is a strong association between obesity and acute lymphoblastic leukemia (ALL) leukemia, but the underlying mechanisms remain poorly understood.[30, 31, 32] Patients with ALL have a high risk of obesity after treatment.[33, 34] In addition, diet‐induced obesity can accelerate the development of ALL in mouse models.[35] The leptin signaling pathway is also desensitized in ALL patients, even after the tumor has been cured, leading to the development of obesity following treatment. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.