LEP and obesity due to melanocortin 4 receptor deficiency: Leptin is an important adipocyte‐derived hormone and the first‐identified messenger to carry peripheral information about energy cues to the central nervous system.[23, 24] However, initial hopes for leveraging the anorectic effect of leptin for treating obesity quickly diminished, as the hormone is ineffective in creating satiety and suppressing food intake, despite the presence of high levels of circulating leptin in murine models of obesity and in obese humans.