LEP and Obesity: Notably, in most human populations, there is a strong association between obesity and acute lymphoblastic leukemia (ALL) leukemia, but the underlying mechanisms remain poorly understood.[30, 31, 32] Patients with ALL have a high risk of obesity after treatment.[33, 34] In addition, diet‐induced obesity can accelerate the development of ALL in mouse models.[35] The leptin signaling pathway is also desensitized in ALL patients, even after the tumor has been cured, leading to the development of obesity following treatment.