Actually, in Cry1−/− mice, only partial resistance to HFD‐induced obesity was observed (≈18%),[19, 22] while in the current study, a much greater effect was observed in body weight reduction following Kdm6a inhibition, which may suggest that Cry1 is not the only mediator and additional studies are needed to fully understand the underlying molecular mechanism. Here, KDM6A is linked to obesity due to melanocortin 4 receptor deficiency.