<h4>Introduction</h4>Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare autosomal recessive disease characterized by ADAMTS13 deficiency or a severe decrease in its activity that is caused by homozygous or combined heterozygous mutations in its encoding gene. This evidence concerns the gene ADAMTS13 and thrombotic thrombocytopenic purpura.