Notably, simvastatin has been shown in several studies to improve cognitive performance, reduce the levels of Aβ peptides, and prevent neuronal loss in AD through its ability to reduce oxidative stress, inflammation, and apoptosis along with the promotion of IDE secretion and modulation of the PI3K/Akt and MAPK/ERK1/2 pathways [38–41]. The gene discussed is AKT1; the disease is Alzheimer disease.