According to the results, the common target genes were mainly distributed in many signaling pathways such as pathways in cancer, hepatitis B, microRNAs in cancer, MAPK, JAK-STAT, Wnt, and Hippo signaling pathways, suggesting that KCMMs may treat HCC by regulating the tumor microenvironment, tumorigenesis, progression, angiogenesis, metastasis, and so on. Here, SOAT1 is linked to hepatitis B virus infection.