IL6 and erythema multiforme: Similarly, studies in rats also demonstrated that curcumenol, the main active ingredient in zedoary, has antibacterial, anti-inflammatory, antioxidation, antitumor, antiplatelet aggregation, and antithrombotic activities and showed that curcumenol significantly reduces the levels of human macrophage chemoattractant protein-1 (MCP-1), migration inhibition factor (MIF), TNF-α, IL-1β, and IL-6 in the peritoneal fluid in the rat model of EM and has obvious inhibitory effects on inflammatory reactions in the abdominal microenvironment [42].