The top 10 signaling pathways were insulin resistance, HIF-1 signaling pathway, type II diabetes mellitus, acute myeloid leukemia, mTOR signaling pathway, AMPK signaling pathway, FoxO signaling pathway, insulin signaling pathway, Chagas disease (American trypanosomiasis), and nonalcoholic fatty liver disease (NAFLD). Here, INS is linked to American trypanosomiasis.