Finally, we have to say, studies were also performed on other markers and genes, such as Her2 and MDM2 for differentiation between different grades of urothelial carcinoma which, in Moradi Tabrizi et al, study no significant association was found between Her2 expression and different degrees of bladder cancer malignancies (35) and study of Jalali Nadoushan et al., overexpression of MDM2 oncoprotein has been shown to be directly related to bladder tumor’s grade (36). This evidence concerns the gene ERBB2 and urinary bladder cancer.