Wnt/β-Catenin signaling pathway activated EMT [36] to promote the binding of β-Catenin to the nucleus and T cell-specific transcription factor/lymphoenhancer (TCF/LEF) to regulate the expression of E-cadherin, the characteristic factor of EMT, and then affect the occurrence of EMT, which plays a blocking role in the process of tumor invasion and migration. The gene discussed is HNF4A; the disease is neoplasm.