In this study, we analyzed the mRNA levels of HOXBs in tumors and normal tissue and found that the mRNA levels of HOXB1/6/8/9 are significantly downregulated in renal cell carcinoma, while those of HOXB3/4/7 are upregulated in nearly all the tumors, including renal cell carcinoma. The gene discussed is HOXB1; the disease is renal cell carcinoma.