In coexpression analysis, we discovered that HOXB5/6/8/9 were coexpressed with multiple Wnt pathway classical genes and proteins, such as MYC, CTNNB, CCND1, and TP53, which further confirms that HOXBs inhibit the growth of renal carcinoma cells through the Wnt signaling pathway. Here, HOXB5 is linked to renal carcinoma.