The vascular endothelial growth factor (VEGF), a signaling ligand released by epithelial cells, is an important positive angiogenesis regulator (Yang et al., 2014; Zhang et al., 2020) and VEGF signaling plays a significant role in inhibiting the apoptosis and promoting proliferation in tumor cells (Liu et al., 2016). This evidence concerns the gene VEGFA and neoplasm.