T cell proliferation and the production of multiple cytokines, such as interleukin-2 (IL-2), IL-6, IL-10, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ), were significantly higher in the T cells + H22 + TL11a/CD3 + group than in the control group, which also supported the anti-tumor effect of TL11a/CD3. The gene discussed is TNF; the disease is neoplasm.