Today, there are several Food and Drug Administration (FDA)-approved therapies of ccRCC for first-line and second-line standard treatments targeting a wide range of targets, including VEGF (bevacizumab), VEGFR/PDGFR (lenvatinib, cabozantinib, pazopanib, axitinib, sorafenib, and sunitinib), mTOR (everolimus and temsirolimus), PD-1 (nivolumab and pembrolizumab), and PD-L1 (avelumab and atezolizumab) (Yang and Chen, 2020). Here, VEGFA is linked to nonpapillary renal cell carcinoma.