Many previous studies have reported that the PTEN/PI3 k/Akt signaling was involved in EGFR-TKI resistance in the non-small cell lung cancer (NSCLC) (Fang et al., 2012; Pérez-Ramírez et al., 2015; Wang et al., 2018; Choi et al., 2019). This evidence concerns the gene EGFR and non-small cell lung carcinoma.