YTHDF1 and ovarian cancer: Jiang et al. (2020) reported that the RNA demethylase ALKBH5 promotes the development of ovarian cancer in a simulated tumor microenvironment through stimulation of the nuclear factor-κB pathway. YTHDF2, an m6A mRNA reader inhibited by miR-145, plays a role in the proliferation, migration, and apoptosis of ovarian cancer cells (Li et al., 2020). YTHDF1 can upregulate the expression of TRIM29 to promote cisplatin resistance in ovarian cancer (Hao et al., 2021).