Genes known to be highly associated with brucellosis contain multiple SNP sites, such as TGF-β (Bravo et al., 2008; Rafiei et al., 2007), IFN-γ (Bravo et al., 2003; Rasouli and Kiany, 2007; Hedayatizadeh-Omran et al., 2010; Eskandari-Nasab et al., 2013), TNF-α (Caballero et al., 2000; Davoudi et al., 2006; Batikhan et al., 2010), IL-15 (Kalani et al., 2011), and TNF-α (Caballero et al., 2000; Kalani et al., 2011). This evidence concerns the gene TNF and brucellosis.