ADCY2 and brucellosis: ADCY2 can catalyze the formation of signal molecule cAMP in response to G protein signal transduction, and downstream signal transduction cascade mediates the change in gene expression patterns, leading to increased IL-6 production (Ding et al., 2004), which is involved in the development of the chief complications of brucellosis (Karaoglan et al., 2009).