For example, although STAT1 mRNA levels are both increased in lupus and normal CD8+ T cells with IFN-α stimulation, the signature of hypomethylated DNA sites in lupus CD8+ T cells facilitates the upregulation of HLA-DRB1 in a STAT1-signaling-dependent manner (91). Here, STAT1 is linked to systemic lupus erythematosus.