In mice with deoxycorticosterone acetate and saline (1K/DOCA/salt)-induced hypertension, the mRNA levels of NLRP3, ASC, pro-caspase-1 and pro-IL-1β were evaluated, as well as the protein expression of active caspase-1 and mature IL-1β (53). Here, NLRP3 is linked to hypertensive disorder.