Some in vitro and in vivo experiments showed that zinc finger antisense 1 (ZFAS1), as the long noncoding RNA of miR-590-3p regulating AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) signal transduction under induction of the transcription factor SP1, could induce cardiomyocyte pyroptosis and aggravate sepsis-induced cardiac dysfunction (62). This evidence concerns the gene MTOR and Sepsis.