IL10 and combined immunodeficiency: In the present report, we extended our novel strategy by confirming that i) a curcumin-based formulation is also atheroprotective when following the same dose, route, and scheme of administration, ii) the formulation was also protective in a second relevant animal model of CID, such as autoimmune neuroinflammation, and iii) the neuroprotective effect depends on the production of IL-10 and could also be elicited after disease triggering.