For the setup of a broadly applicable peptide warehouse, we focused on the 532 non-mutated peptides presented by ≥ 20% of (HLA-matched) CLL samples comprising 82 HLA-A*02-, 105 HLA-A*24-, 127 HLA-B*07-, and 218 HLA class II-restricted peptides (Supplementary Tables 5–8). This evidence concerns the gene HLA-A and B-cell chronic lymphocytic leukemia.