Our results together with evidence from the literature that TNFR1 contributes to fibrotic liver injury (18), insulin resistance (40) and hepatocellular carcinoma formation in NAFLD (41, 42) indicate that TNFR1 is a promising novel drug target for NAFLD and highlight the potential of Atrosimab as a novel therapeutic to treat NAFLD. This evidence concerns the gene TNFRSF1A and hepatocellular carcinoma.