Moreover, we obtained the validation data of 27 presymptomatic patients (non-severe, n=25; severe, n=2) from another study center (the First People’s Hospital, Jiangxia District, Wuhan, China) and found that the levels of N-Terminal-proBNP (NT-proBNP), PCT, magnesium, etc., were high in severely ill COVID-19 patients (Figure 4F). Here, NPPB is linked to COVID-19.