G6PC3 and hyperinsulinemic hypoglycemia, familial, 4: It is known that G6Pase-deficiency can impair glycolysis and hexose monophosphate shunt activities, leading to reductions in nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, and glycolysis was impaired in patients with G6PC3 deficiency (10, 28).