Interleukin-25 (IL-25) induces myofibroblast differentiation, extracellular matrix production and matrix metalloprotease expression in nasal fibroblasts via the NF- κB signaling pathway, thus aiding the process of the tissue growth and leading to nasal polyposis in chronic rhinosinusitis (210). The gene discussed is IL25; the disease is chronic rhinosinusitis.