Downregulates atherothrombosis, inactivates platelet aggregation and cancer metastasis in esophageal and gastro-intestinal cancers. Inhibits angiogenesis in gastric cancer. Enhances nitric oxide production leading to IKKβ-mediated inhibition of NF-κB activity in gastric, prostate and breast cancer stem cells. Here, IKBKB is linked to gastric cancer.