Our recently established ER-stress related Sjögren’s syndrome animal model of ERdj5 knockout in mice (ERdj5-/-) also strengthens this connection: ERdj5 is a chaperone protein involved in the ER-associated protein degradation (ERAD) pathway and its removal in mice results in the development of pathological characteristics of SS, like salivary gland inflammatory infiltrations, anti-SSA/Ro and anti-SSB/La autoantibodies, xerostomia and a marked predilection towards female individuals (8). This evidence concerns the gene DNAJC10 and xerostomia.