We first assessed the expression and prognostic significance of CD161 in pan-cancer and found that its expression was high in 14 tumours, including ACC, CESC, ESCA, GBM, KIRC, KIRP, LAML, LGG, OV, PAAD, READ, SKCM, STAD, and TGCT. The gene discussed is KLRB1; the disease is glioblastoma.