A study in humanized transgenic mice expressing a myelin-specific T cell receptor derived from a CD8 T cell clone from an individual patient along with HLA-A*0301 or HLA-A*0201 showed an opposite effect of these alleles on the development of experimental autoimmune encephalomyelitis, suggesting a potential link between MS genetic risk and CD8 T cell-mediated autoimmune demyelination (96). This evidence concerns the gene HLA-A and myeloid sarcoma.