CD4 and myeloid sarcoma: Earlier work performed by van Noort and colleagues suggested that EBV-induced expression of the small heat shock protein alpha B-crystallin in B cells and HLA-DR-restricted presentation of this protein may activate autoreactive proinflammatory CD4 T cells that recognize stress-induced alpha B-crystallin in oligodendrocytes and astrocytes in MS lesions (77, 161).