We have repeatedly visualized CD8 T cells that adhere to, form immunological synapses with and polarize perforin or granzyme B towards B cells, plasma cells and cells expressing EBV lytic proteins in white matter and grey matter lesions and in the inflamed meninges in postmortem brain tissue from progressive MS patients (53, 63, 117, 173). This evidence concerns the gene GZMB and myeloid sarcoma.