CD8A and Epstein-Barr virus infection: A recent study in humanized mice (NOD-scid IL2 receptor γ-chain-deficient mice reconstituted with human immune system components) has shown less efficient recognition of EBV-transformed B cell lines by HLA-DR15-restricted CD4 T cell clones, increased CD8 T cell expansion and activation, and higher EBV DNA load in HLA-DR15 donor-reconstituted mice after EBV infection (105).