Recently, it was reported that short term CD4 and CD8 T cell lines derived from the CSF of patients with CIS and definite MS (154) and from the CSF and brain tissue obtained from chronic MS patients at autopsy (62) showed no reactivity towards several candidate MS associated autoantigens, like myelin (MAG, MBP, MOG, PLP), glial (Kir4.1, S100B) and neuronal (contactin-2, neurofascin) antigens, and alpha B-crystallin presented by autologous EBV-transformed B cell lines or an allogeneic HLA-matched EBV-transformed B cell line stably transduced with these human antigens. This evidence concerns the gene S100B and myeloid sarcoma.