Some studies have shown that CD8 T cell responses to major myelin proteins [MBP, proteolipid protein (PLP), myelin-associated glycoprotein (MAG), myelin oligodendrocyte glycoprotein (MOG)] (147, 148) or other oligodendrocyte proteins (149) are increased in MS patients compared to healthy subjects whereas other studies report no differences (150–152). This evidence concerns the gene MAG and myeloid sarcoma.