Additionally, the ISG score, i.e. the mean expression of six ISGs (IFI27, IFI44L, IFIT1, RSAD2, SIGLEC1, and ISG15) defining a type I IFN response was significantly lower in the RP patient and severe patients compared to MM patients (Figure 5D) (26). Here, SIGLEC1 is linked to Miyoshi myopathy.