Jag1Ab attenuated the H. pylori-induced mRNA expression of Hes1 (Figure 8A), suggesting the inhibition of Notch signaling, which corresponded to the study in which the addition of Jagged1 antibody effectively blocked the axis of the Jagged1-Notch signaling pathway in chronic lymphoid leukemia. This evidence concerns the gene HES1 and lymphoid leukemia.