Indeed, specific deletion of CB1R in RPTC (RPTC-CB1R-/-) did not prevent obesity in mice, but significantly reduced the obesity-induced lipid accumulation in the kidney as well as renal dysfunction, urinary albumin-to-creatinine ratio (ACR), inflammation, and renal fibrosis. The gene discussed is CNR1; the disease is obesity due to melanocortin 4 receptor deficiency.