CNR1 and type 2 diabetes nephropathy: In addition, in cultured podocytes in vitro, high glucose stimulation increased CB1R expression whereas rimonabant abolished high-glucose-induced up-regulation of collagen and plasminogen activator inhibitor-1 synthesis, also suggesting that CB1R blockade protected against renal injury through both metabolic and antifibrotic effects in type 2 diabetic nephropathy (14).