Among non-demyelinating antibody-mediated CNS disorders, longitudinally extensive tract-restricted MRI abnormalities on T2 and T1-post gadolinium sequences, particularly along lateral columns (Figure 1E), are characteristic of the rare paraneoplastic myelopathies and most often accompanied by CRMP5/anti-CV2 or amphiphysin autoantibodies (71). This evidence concerns the gene AMPH and central nervous system disorder.