PDE10A and amyotrophic lateral sclerosis: Chorea and hyperkinetic movement disorders with basal ganglia T2-abnormalities on MRI may occur with PDE10A and CRMP5 autoantibodies (80, 81); while non-REM sleep disturbances are characteristically seen with autoantibodies targeting IgLON5, sometimes in association with progressive bulbar dysfunction and muscular fasciculations that can mimic progressive supranuclear palsy or amyotrophic lateral sclerosis (27, 82).