As shown in Figures 5A–C, the protein kinase R-like endoplasmic reticulum kinase (PERK), C/EBP-homologous protein (CHOP), and activating transcription factor 6 (ATF-6) messenger RNA (mRNA) levels in cardiomyocytes were significantly upregulated in response to hyperglycemia treatment. The gene discussed is EIF2AK3; the disease is Hyperglycemia.