Several studies have demonstrated that the neurosteroid dehydroepiandrosterone (DHEA) serves as an endogenous ligand for Sigmar1, and DHEA treatment ameliorated PO-induced cardiac hypertrophy in ovariectomized rats (Bhuiyan and Fukunaga, 2009; Bhuiyan et al., 2011a; Tagashira et al., 2011). Here, SIGMAR1 is linked to cardiac hypertrophy.