ER-stress (induced by tunicamycin or thapsigargin) transcriptionally increased Sigmar1 protein levels via the PERK/eIF2α/ATF4 pathway and ameliorated cell death signaling under in HEK293 cells or mouse neuroblastoma (Neuro2a) cells (Mitsuda et al., 2011). Here, SIGMAR1 is linked to neuroblastoma.