Further studies of the role of Sigmar1 in COVID-19 have suggested a functional host-dependency factor for SARS-CoV-2; the absence of Sigmar1 by knockdown reduced the replication of SARS-CoV-2 protein, delaying disease progression and presenting Sigmar1 as an attractive therapeutic target (Gordon et al., 2020a). This evidence concerns the gene SIGMAR1 and COVID-19.