SIGMAR1 and cardiac hypertrophy: Temporal study performed to demonstrate the time-dependent changes in Sigmar1 protein levels in the heart showed a significant negative linear correlation with the development of cardiac dysfunction in pressure overload-induced (PO) or transverse aortic constriction (TAC)-induced cardiac hypertrophy (Bhuiyan et al., 2010; Tagashira et al., 2010).