The disturbed process of angiogenesis which relies on a variety of signaling pathways may play a major role, since it has been shown that elevated Angiopoietin-2 (Ang-2) with declined Angiopoietin-1 (Ang-1) expression (Cui et al., 2011; Ye et al., 2011) and decreased vascular endothelial growth factor (VEGF) with increased angiostatin signaling (Zhu et al., 2010) are involved in dysfunctional cerebral neovascularization in diabetes. This evidence concerns the gene VEGFA and diabetes mellitus.