In our study, we have shown that prior to cerebral ischemia, VEGF-A mRNA and Ang-2 mRNA were significantly increased in the cortex in the diabetic group compared with the non-diabetic group, while mRNAs for Ang-1, TGF-β, and PDGF-β were slightly increased, which may suggest the brain microvasculature in diabetic rat is immature. Here, ANGPT2 is linked to brain ischemia.