Therefore, although the causality cannot be strictly verified, we highly suspect that the baseline cerebral microvasculopathy and activated Jagged1-Notch1 signaling in T2DM before ischemic stroke is at least partly responsible for the delayed angiogenesis as well as suppressed Jagged1-Notch1 signaling which cannot be further stimulated after pMCAO. This evidence concerns the gene NOTCH1 and type 2 diabetes mellitus.