Our study has shown that after ischemic stroke the expression of Notch1, Jagged1 and HES1 on ECs at D1, D3, and D7 in NDI group was significantly increased, while in DI group, the expressions of Notch1, Jagged1, and Hes1 in the peri-infarct region were not increased where there was delayed angiogenesis at acute phase. The gene discussed is HES1; the disease is ischemic stroke.