Expression data in patients, and in particular upregulation of primarily MYOG and then CSNK1ε and SIRT1, together with the absence of specific studies in Duchenne patients in literature, prompted us to further explore if these deregulated transcripts could reflect in the plasma of patients affected by dystrophinopathies. This evidence concerns the gene SIRT1 and neuromuscular disease caused by qualitative or quantitative defects of dystrophin.