COL3A1 and Alzheimer disease: Previous studies have shown that the occurrence of AD is associated with mutations in certain genes, such as FBN1, COL3A1, TGBFR1, and ACTA2. In addition to these genetic factors, there are other risk factors for AD such as hypertension, dyslipidemia, and smoking (Ohno-Urabe et al., 2018).